Medical Implant Research
Implants are riquired whenever the severity of tissue defects or the loss of functionality of the tissue prevent natural healing. The most common materials in orthopaedic implants are cobalt-chrome, titanium, ceramics and polyethylene.
The direct communication between our surgeons and the manufacturing industry enables us as a research and clinical facility, to conflate the evaluation of requirements and the technical possibilities of implants in one institution.
The interaction between autologous tissue and external material can be influenced considerably by changes of the surface areas of implants. In addition, the composition and the structure of the surfaces influence the adherence of bacteria that can cause infections of protheses. At our laboratories we test the surfaces of implants on their biocompability and examin the interaction of implants with living cells.
Those interactions can further be altered by linking the implants with biologically active substances such as growth factors or medication. Our team also conducts clinical research in the field of replacement endoprosthetics. Subject to research are techniques to increase accuracy of diagnostics in case of an infection or loosening of artificial joints, to enable the surgeons to choose the best possible operation method. At the same time conlusions regarding the origin of the complications can be drawn from this that help to improve future implant development.
Association for Orthopedic Research (AFOR):
”Gene expression analysis of periprosthetic tissue samples in septic and aseptic loosened endoprostheses – a clinical and diagnostic interdisciplinary research project with a future.”
”Significance of RANK/RANKL/OPG-systems and new markers of infection in differential diagnostics of septic vs. aseptic loosened prostheses.”